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Vaccination: Malaria Vaccine
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Total 1526 results found since Jan 2013.
Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets
In this study, we infected pregnant first parity gilts in their first, second and third trimesters of gestation with PEDV to determine the impact of stage of gestation on generation of maternal B-cell immunity, the gut-MG-sIgA axis and lactogenic immune protection in PEDV challenged piglets. Our goal was to identify innate and adaptive immune factors during pregnancy that influence lymphocyte trafficking, in addition to immune correlates of lactogenic immune protection in neonatal suckling piglets. Understanding the impact of stage of gestation at PEDV infection or exposure on maternal immunity will allow more precise mate...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research
WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships
Publication date: Available online 19 September 2014 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Roopa Ramamoorthi , Katy M. Graef , Jennifer Dent Neglected tropical diseases (NTDs), malaria, and tuberculosis have a devastating effect on an estimated 1.6billion people worldwide. The World Intellectual Property Organization (WIPO) Re:Search consortium accelerates the development of new drugs, vaccines, and diagnostics for these diseases by connecting the assets and resources of pharmaceutical companies, such as compound libraries and expertise, to academic or nonprofit researchers w...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 12, 2014 Category: Parasitology Source Type: research
Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets.
Abstract
Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects more than 240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is currently limited to a single drug, Praziquantel, which is quite effective with a single-day treatment and virtually no host-toxicity. Recently, however, the ...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - July 20, 2017 Category: Biochemistry Authors: El Kouni MH Tags: Comp Biochem Physiol B Biochem Mol Biol Source Type: research
Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a spe...
Source: Frontiers in Pharmacology - September 22, 2021 Category: Drugs & Pharmacology Source Type: research
Gauche(+) side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine.
Abstract
Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. Most of those which did not interfere, compete, inhibit or suppress their individual VHLLAI or FPIPS activity contained or displayed ...
Source: Vaccine - February 27, 2014 Category: Allergy & Immunology Authors: Bermúdez A, Calderon D, Moreno-Vranich A, Almonacid H, Patarroyo MA, Poloche A, Patarroyo ME Tags: Vaccine Source Type: research
Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets
Publication date: Available online 21 July 2017 Source:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Author(s): Mahmoud H. el Kouni Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects more than 240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is curren...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - July 21, 2017 Category: Molecular Biology Source Type: research
Rwanda: Rwanda Optimistic About Latest Breakthrough in Search for a Malaria Vaccine
[New Times] Officials at Rwanda Biomedical Centre (RBC) have said they are optimistic about the recent unprecedented developments in the search for a malaria vaccine, and hope soon there will be a vaccine to complement the existing measures to fight the disease.
Source: AllAfrica News: Malaria - April 26, 2021 Category: Infectious Diseases Source Type: news
What Health Risks Does Climate Change Pose?
Discussion
Japanese encephalitis virus (JEV) is a Flavivirae, arbovirus that is endemic to many areas of Asia and the Pacific. It is estimated to affect ~70,000 people/year with ~10-15,000 deaths yearly in 20 countries, with a fatality rate of 35-40%. It can cause encephalitis and irreversible neurological morbidity. JEV is spread by Culex mosquitos which feed on swine. Increased environmental temperature and increased humidity (warm air is more moist) increases mosquito numbers, their survivability and ultimate dissemination. China has the highest rates of JEV with particular areas being more prone, as some areas co-farm ...
Source: PediatricEducation.org - March 6, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools
Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can accelerate the design of novel and next generation vaccines and their delivery to the clinic. Over the past 20 years, vaccinologists, bioinformatics experts, and advanced programmers based in Providence, Rhode Island, USA have advanced the development of an integrated toolkit for vaccine design called iVAX, that is secure and user-accessible by internet. This integrated set of immu...
Source: Frontiers in Immunology - April 6, 2020 Category: Allergy & Immunology Source Type: research
Ebola virus threat to the UK is 'very low'
Health news has been dominated in recent days by the outbreak of the Ebola virus in west Africa, with more than 1,200 confirmed cases and 672 deaths.
Cases have been confirmed in Sierra Leone, Liberia and Guinea. The World Health Organization estimates the current outbreak has a mortality rate of 56%.
It is important to note there is currently no direct threat to people in the UK from the Ebola virus.
Outbreaks of Ebola are nothing new, but health professionals are concerned about the size of the outbreak.
The majority of cases are confined to rural areas, but there has been a reported case of a man infected with the vi...
Source: NHS News Feed - July 31, 2014 Category: Consumer Health News Tags: QA articles Source Type: news
UK Ebola case confirmed but risk remains low
A case of Ebola has now been confirmed in the UK but the risk of Ebola to the general public remains very low. Ebola can only be transmitted by direct contact with the blood or bodily fluids of an infected person.
The UK case - in a healthcare worker in Scotland who arrived in Glasgow from Sierra Leone on Sunday - has been confirmed by the Scottish government. The patient was placed in isolation at Glasgow's Gartnavel Hospital and will be transferred for specialised care at the Royal Free Hospital in London.
The healthcare worker left Sierra Leone on December 28 and was a passenger on flight AT596 from Freetown to ...
Source: NHS News Feed - December 29, 2014 Category: Consumer Health News Tags: QA articles Source Type: news
Title: The WASH Approach: Fighting Waterborne Disease in Emergency Situations
Refugees collect water from a public tap stand in an Adjumani settlement. © Wendee Nicole
Rhino Camp, Arua District. Refugees in Uganda live on land donated by Ugandan nationals. Refugee families are given plots on which they can build temporary shelters and grow crops.© Wendee Nicole
Oxfam staff members Tim Sutton (left) and Pius Nzuki Kitonyi (right) with the soon-to-be-repaired water pump in Adjumani. In disaster-affected situations, Oxfam takes a lead in delivering WASH-related services.© Wendee Nicole
Hand-operated water pumps are a reliable source of pre...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News Community Health Disaster Response Drinking Water Quality Infectious Disease Infrastructure International Environmental Health Microbial Agents Sanitation Warfare and Aftermath Water Pollution Source Type: research
Ebola risk remains low after UK nurse recovers
The Scottish nurse found to have Ebola after arriving in Glasgow from Sierra Leone has recovered after specialist care at the Royal Free Hospital in London and has been discharged.
She remains the only case confirmed in the UK, and the risk to the general public is very low. Ebola can be transmitted only by direct contact with the blood or bodily fluids of an infected person.
The nurse, Pauline Cafferkey, had been working as a volunteer for Save the Children in Sierra Leone. She left Sierra Leone on December 28 and took flights from Freetown to Casablanca and from Casablanca to London. She then transferred at Heathrow t...
Source: NHS News Feed - February 2, 2015 Category: Consumer Health News Tags: QA articles Source Type: news
Ebola risk remains low as medic flown home
A UK military healthcare worker who was infected with Ebola in Sierra Leone has been flown home and is being treated at the Royal Free Hospital in London.
Four other healthcare workers who had been in contact with the infected person are also being assessed. Two were flown home on the same flight as the infected worker and are now being monitored at the Royal Free. The others are being assessed in Sierra Leone. None of the four has been diagnosed with Ebola.
The latest case follows that of Glasgow nurse Pauline Cafferkey, who was found to have Ebola after arriving in Glasgow from Sierra Leone in December 2014. She reco...
Source: NHS News Feed - March 12, 2015 Category: Consumer Health News Tags: QA articles Source Type: news
